Determination of rate constants for turnover of myosin isoforms in rat myocardium: implications for in vivo contractile kinetics.

@article{Locher2009DeterminationOR,
  title={Determination of rate constants for turnover of myosin isoforms in rat myocardium: implications for in vivo contractile kinetics.},
  author={Matthew R Locher and Maria V. Razumova and Julian E. Stelzer and Holly S Norman and Jitandrakumar R. Patel and Richard L Moss},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={297 1},
  pages={H247-56}
}
The ventricles of small mammals express mostly alpha-myosin heavy chain (alpha-MHC), a fast isoform, whereas the ventricles of large mammals, including humans, express approximately 10% alpha-MHC on a predominately beta-MHC (slow isoform) background. In failing human ventricles, the amount of alpha-MHC is dramatically reduced, leading to the hypothesis that even small amounts of alpha-MHC on a predominately beta-MHC background confer significantly higher rates of force development in healthy… CONTINUE READING
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