Corpus ID: 22662423

Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells.

@article{Liu2005DeterminationOR,
  title={Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells.},
  author={J. Liu and H. Ye and Y. Lou},
  journal={Die Pharmazie},
  year={2005},
  volume={60 2},
  pages={
          120-5
        }
}
To confirm that the estrogenic activity of icariin is based on the close relationship between the structures of its metabolites and the effects of their binding to target hormone receptors, the metabolism of icariin in rat urine was analyzed in vivo, and the estrogenic activity of its metabolites was measured in cultured MCF-7 human breast cancer cells, respectively. By CZE analysis, peaks corresponding to the relative positions of desmethylicaritin and icaritin were observed in the urine… Expand
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  • D. Hao, L. Yang
  • Biology, Medicine
  • Expert opinion on drug metabolism & toxicology
  • 2016
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