Determination of pyrrolizidine alkaloid metabolites from mouse liver microsomes using tandem mass spectrometry and gas chromatography/mass spectrometry.

@article{Winter1988DeterminationOP,
  title={Determination of pyrrolizidine alkaloid metabolites from mouse liver microsomes using tandem mass spectrometry and gas chromatography/mass spectrometry.},
  author={Carl K. Winter and H. J. Segall and A. Daniel Jones},
  journal={Biomedical \& environmental mass spectrometry},
  year={1988},
  volume={15 5},
  pages={
          265-73
        }
}
The rapid and sensitive identification and quantification of important pyrrolizidine alkaloid metabolites using tandem mass spectrometry (MS/MS) and gas chromatography/mass spectrometry (GC/MS) is described. Identifications of N-oxide and hydrolytic metabolites of the pyrrolizidine alkaloids senecionine and monocrotaline in extracts of mouse hepatic microsomal incubations were accomplished by comparing collisionally activated decomposition/mass-analyzed ion kinetic energy spectra of specific… Expand
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