Determination of progabide and its acid metabolite in biological fluids by high-performance liquid chromatography on silica column with ultraviolet detection.


A high-performance liquid chromatographic method has been developed for the determination of progabide and its main acid metabolite in blood, serum and plasma. The assay involved a single and rapid extraction of drug and metabolite into toluene from the biological matrix buffered at pH 4.8, evaporation of the organic phase, and chromatography of the… (More)


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