Determination of porosity and pore-size distribution of aspirin tablets relevant to drug stability.

@article{Gucluyildiz1977DeterminationOP,
  title={Determination of porosity and pore-size distribution of aspirin tablets relevant to drug stability.},
  author={H Gucluyildiz and G S Banker and Garnet E. Peck},
  journal={Journal of pharmaceutical sciences},
  year={1977},
  volume={66 3},
  pages={407-14}
}
Total porosity and pore-size distribution of aspirin tablets prepared from aspirin, starch USP, and precipitated colloidal silicon dioxide were determined using mercury porosimetry. The model represented a hydrolyzable drug substance in combination with simple excipients. The role of starch and silicon dioxide on the microstructure of the tablets was investigated, as was the chemical stability of various systems. In general, the porosity of tablets containing a constant quantity of starch… CONTINUE READING