Determination of pore-lining residues in the hepatitis C virus p7 protein.

  title={Determination of pore-lining residues in the hepatitis C virus p7 protein.},
  author={Chee Chew and Ranjit Vijayan and Jason C Chang and Nicole Zitzmann and Philip C. Biggin},
  journal={Biophysical journal},
  volume={96 2},
The p7 protein from hepatitis C virus is critical for the assembly and secretion of infectious virus, making it an attractive drug target. It is thought to be a viroporin with a demonstrated ion channel activity when reconstituted into planar lipid bilayers. Electron microscopy experiments suggest that p7 oligomers coexist as hexamers and heptamers. Proposed models of p7 oligomers assume the N-terminal helix to be the pore lining helix. Here, we demonstrate, via electrophysiology, that Cu(2… CONTINUE READING
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The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy.

Proceedings of the National Academy of Sciences of the United States of America • 2009
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