• Medicine
  • Published in Cancer research 1992

Determination of plasma urokinase-type plasminogen activator antigen in patients with primary liver cancer: characterization as tumor-associated antigen and comparison with alpha-fetoprotein.

@article{Huber1992DeterminationOP,
  title={Determination of plasma urokinase-type plasminogen activator antigen in patients with primary liver cancer: characterization as tumor-associated antigen and comparison with alpha-fetoprotein.},
  author={Kurt Huber and Johannes C. Kirchheimer and D Ermler and Clayton Bell and Bernd R. Binder},
  journal={Cancer research},
  year={1992},
  volume={52 7},
  pages={
          1717-20
        }
}
We determined the plasma levels of urokinase-type plasminogen activator (u-PA) antigen and alpha-fetoprotein (AFP) in 44 patients with different stages of liver cirrhosis and in 29 patients with liver cirrhosis-based primary liver cancer at the time of first clinical detection of the malignant disease. Sensitivity values of u-PA and AFP in detecting primary liver cancer were 57 and 62%, respectively, and specificity values were 95 and 86%, respectively. A combination of both markers led to a… CONTINUE READING