Determination of plasma concentrations of losartan in patients by HPLC using solid phase extraction and UV detection.

Abstract

PURPOSE To establish a HPLC assay for plasma losartan and its active metabolite EXP3174 to facilitate clinical pharmacokinetic studies. METHODS the HPLC system consisted of a 250 x 2 mm i.d. C18 reversed phase column preceded by a 4 x 4 mm guard column, a UV detector set at 254 nm, and an integrator. The mobile phase was a mixture of 0.01 M ammonium… (More)

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@article{Yeung2000DeterminationOP, title={Determination of plasma concentrations of losartan in patients by HPLC using solid phase extraction and UV detection.}, author={P. Yeung and Alan J. Jamieson and G. J. Smith and Debra Fice and P. Timothy Pollak}, journal={International journal of pharmaceutics}, year={2000}, volume={204 1-2}, pages={17-22} }