Determination of phosphonoformic acid in human plasma and urine by high-performance liquid chromatography with electrochemical detection.


Trisodium phosphonoformate (foscarnet) is used in the treatment of cytomegalovirus infections in immunocompromised patients, such as bone marrow and renal transplant recipients, as well as patients with the acquired immune deficiency syndrome. A simple high-performance liquid chromatographic assay is described using an electrochemical detector. The method… (More)


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