Determination of phenolic ionization constants of anthracyclines with modified substitution pattern of anthraquinone chromophore.

@article{Razzano1990DeterminationOP,
  title={Determination of phenolic ionization constants of anthracyclines with modified substitution pattern of anthraquinone chromophore.},
  author={Giuseppe Razzano and Vincenzo Rizzo and Aristide Vigevani},
  journal={Farmaco},
  year={1990},
  volume={45 2},
  pages={215-22}
}
The phenolic ionization constants in aqueous solution of doxorubicin, daunorubicin and nine daunorubicin analogues with different substitution patterns at the anthraquinone moiety have been determined spectrophotometrically upon taking into account aggregation effects with extrapolation to infinite dilution. In contrast with an early literature report [Sturgeon, R.J. & Schulman, S.G. J. Pharm. Sci. 66, 958-961; 1977] the perturbation from amino group ionization on daunosamine sugar was found to… CONTINUE READING

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