Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, rabbit and bovine eyes.

@article{Loch2012DeterminationOP,
  title={Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, rabbit and bovine eyes.},
  author={Christian Loch and Simon Žakelj and Albin Kristl and Stefan Nagel and Rudolf F. Guthoff and Werner Weitschies and Anne Seidlitz},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2012},
  volume={47 1},
  pages={131-8}
}
To treat ophthalmic diseases like glaucoma or inflammatory disorders topically applied ophthalmic formulations such as eye drops are usually used. In addition, novel ophthalmic implants releasing drug substances locally into different parts of the eye are available today. In the work presented here, the permeability coefficients of selected drugs (ciprofloxacin hydrochloride, lidocaine hydrochloride, timolol maleate) for ophthalmic tissues were determined using side-by-side diffusion chambers… CONTINUE READING
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