Determination of perfluorooctanoic acid and perfluorooctanesulfonate in human tissues by liquid chromatography/single quadrupole mass spectrometry.

@article{Maestri2006DeterminationOP,
  title={Determination of perfluorooctanoic acid and perfluorooctanesulfonate in human tissues by liquid chromatography/single quadrupole mass spectrometry.},
  author={Luciano Maestri and Sara Negri and Massimo Ferrari and Sergio Ghittori and Francesca Fabris and Paolo Danesino and Marcello Imbriani},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2006},
  volume={20 18},
  pages={2728-34}
}
A method is described that permits the measurement of the levels of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in human liver, kidney, adipose tissue, brain, basal ganglia, hypophysis, thyroid, gonads, pancreas, lung, skeletal muscle and blood, even in subjects not occupationally exposed to these compounds. The purification of samples involved the use of trifunctional (tC18) and strong anion-exchange (SAX) solid-phase extraction cartridges, and the analysis utilized a… CONTINUE READING
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