Determination of parthenolide in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study.

@article{Zhao2016DeterminationOP,
  title={Determination of parthenolide in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study.},
  author={Ai-qin Zhao and Ji-hong Zhao and Shu-qing Zhang and Yong-yang Pan and Xu-lei Huo},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2016},
  volume={119},
  pages={99-103}
}
A rapid, sensitive and selective ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the determination and pharmacokinetic investigation of parthenolide in rat plasma. Sample preparation was accomplished through a simple one-step deproteinization procedure with 0.2mL of acetonitrile containing 30ng/mL of pirfenidone (IS), and to a 0.1mL plasma sample. Plasma samples were separated by UPLC on an Acquity UPLC BEH C18 column using a… CONTINUE READING

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