Determination of paraoxonase 1 status without the use of toxic organophosphate substrates.

@article{Richter2008DeterminationOP,
  title={Determination of paraoxonase 1 status without the use of toxic organophosphate substrates.},
  author={Rebecca J. Richter and Gail P. Jarvik and Clement E. Furlong},
  journal={Circulation. Cardiovascular genetics},
  year={2008},
  volume={1 2},
  pages={147-52}
}
Paraoxonase 1 (PON1) is a member of a tandem 3-gene family localized on human chromosome 7q21-22.1 High-density lipoprotein-associated PON12,3 and PON34,5 are synthesized primarily in the liver, whereas PON2 is ubiquitously expressed.1 PON1 was initially characterized and named for its ability to hydrolyze paraoxon, the toxic oxon metabolite of parathion.6 Although Aldridge6 proposed in 1953 that serum paraoxonase (POase) and arylesterase (AREase) activities were carried out by the same enzyme… CONTINUE READING

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