Determination of oxyphenonium bromide in plasma and urine by means of ion-pair extraction, derivatization and gas chromatography-electron-capture detection.

@article{Greving1977DeterminationOO,
  title={Determination of oxyphenonium bromide in plasma and urine by means of ion-pair extraction, derivatization and gas chromatography-electron-capture detection.},
  author={Jan E. Greving and J. H. G. Jonkman and F Fiks and Rokus A de Zeeuw and L E van Bork and N. G. M. Orie},
  journal={Journal of chromatography},
  year={1977},
  volume={142},
  pages={611-9}
}
A sensitive and selective method for the determination of the quaternary ammonium compound oxyphenonium bromide (Antrenyl), a drug with strong anticholinergic properties, in human plasma and urine is described. The method is based on ion-pair extraction of the cation with perchlorate, a re-extraction according to ion-pair principles with tetrapentylammonium… CONTINUE READING