Determination of orally coadministered nadolol and its deuterated analogue in human serum and urine by gas chromatography with selected-ion monitoring mass spectrometry.

@article{Cohen1984DeterminationOO,
  title={Determination of orally coadministered nadolol and its deuterated analogue in human serum and urine by gas chromatography with selected-ion monitoring mass spectrometry.},
  author={A. Cohen and R. G. Devlin and E. Ivashkiv and P. T. Funke and T. McCormick},
  journal={Journal of pharmaceutical sciences},
  year={1984},
  volume={73 11},
  pages={
          1571-5
        }
}
  • A. Cohen, R. G. Devlin, +2 authors T. McCormick
  • Published 1984
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • A cartridge serum and urine extraction procedure of the beta-adrenergic antagonist, nadolol, employing a cross-linked styrene-divinyl benzene macroreticular resin is described. Samples were analyzed as the silylated derivative by gas chromatography-mass spectrometry (GC-MS) using selected-ion monitoring. When nadolol was orally coadministered with its deuterated analogue, relative bioavailability could be demonstrated with six or fewer subjects. Employing a base-deactivated GC phase, the limit… CONTINUE READING
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