Determination of optimal vitamin C requirements in humans.

@article{Levine1995DeterminationOO,
  title={Determination of optimal vitamin C requirements in humans.},
  author={M. Levine and K. Dhariwal and R. Welch and Y. Wang and J. Park},
  journal={The American journal of clinical nutrition},
  year={1995},
  volume={62 6 Suppl},
  pages={
          1347S-1356S
        }
}
Although the recommended dietary allowance provides an estimate for vitamin C ingestion in humans, optimal vitamin C requirements are unknown. We define optimal vitamin C requirements operationally based on the following: dose-function relations, availability in the food supply, steady state concentrations in plasma and tissues achieved at each dose of vitamin C, urinary excretion, bioavailability, toxicity, and epidemiologic observations. Optimal vitamin C requirements can be estimated when… Expand
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