Determination of optimal duration of mechanical unloading for failing hearts to achieve bridge to recovery in a rat heterotopic heart transplantation model.

@article{Oriyanhan2007DeterminationOO,
  title={Determination of optimal duration of mechanical unloading for failing hearts to achieve bridge to recovery in a rat heterotopic heart transplantation model.},
  author={Wunimenghe Oriyanhan and Hiroshi Tsuneyoshi and Takeshi Nishina and S. Matsuoka and Tadashi Ikeda and Masashi Komeda},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2007},
  volume={26 1},
  pages={16-23}
}
BACKGROUND Mechanical unloading (MU) of a failing heart using a left ventricular assist device (LVAD) can lead to "bridge to recovery" in some patients. However, it is still unknown how to determine when to withdraw assistance. We sought to determine the optimal duration of MU by investigating its short- and long-term effects using a rat model of heterotopic heart transplantation. METHODS Heart failure (HF) was induced in Lewis rats by ligating the left anterior descending artery. In the MU… CONTINUE READING
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