Determination of optical impurity of pregabalin by HPLC with pre-column chiral derivatization.

Abstract

A new method for determining the optical impurity of Pregabalin is developed. The method is based on Pregabalin, and its isomers can be derivatized with Na-5-fluoro-2,4-dinitrophenyl-5-L-alanine amide. These derivated compounds can be separated by an ordinary chromatography column (Inertsil ODS-2.5 microm, 250 mmx4.6 mm i.d.). Phosphoric acid buffer and… (More)

Topics

Cite this paper

@article{Chen2008DeterminationOO, title={Determination of optical impurity of pregabalin by HPLC with pre-column chiral derivatization.}, author={Xiao-hui Chen and Daolin Zhang and Jie Deng and Xiaotai Fu}, journal={Journal of chromatographic science}, year={2008}, volume={46 1}, pages={42-4} }