Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry.


BACKGROUND The development of therapies for lysosomal storage disorders has created a need for biochemical markers to monitor the efficacy of therapy and methods to quantify these markers in biologic samples. In Pompe disease, the concentration of a tetrasaccharide, consisting of four glucose residues, is reputedly increased in urine and plasma, but faster… (More)


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