Determination of nonsteroidal anti-inflammatory drugs in human plasma by LC-MS-MS with a hydrophilic polymer column

@article{Lee2010DeterminationON,
  title={Determination of nonsteroidal anti-inflammatory drugs in human plasma by LC-MS-MS with a hydrophilic polymer column},
  author={X Hey-Kyoung Lee and Takeshi Kumazawa and Chika Hasegawa and Tetsuya Arinobu and Akihito Kato and Hiroshi Seno and Keizo Sato},
  journal={Forensic Toxicology},
  year={2010},
  volume={28},
  pages={96-104}
}
Six nonsteroidal anti-inflammatory drugs (NSAIDs) in human plasma samples were analyzed by liquid chromatography (LC)-electrospray ionizationtandem mass spectrometry (MS-MS) using a hydrophilic polymer column (MSpak GF-310 4B), which enabled direct injection of crude biological samples. Separation of the six NSAIDs, alminoprofen, flurbiprofen, ibuprofen, pranoprofen, tiaprofenic acid, and zaltoprofen, was carried out using gradient elution with 10 mM ammonium acetate/acetonitrile. The mass… CONTINUE READING
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