Determination of nitroimidazole residues in porcine urine by liquid chromatography/tandem mass spectrometry.

@article{Xia2006DeterminationON,
  title={Determination of nitroimidazole residues in porcine urine by liquid chromatography/tandem mass spectrometry.},
  author={X Q Xia and Xiaowei Li and Jianzhong Shen and Suxia Zhang and Shuangyang Ding and Haiyang Jiang},
  journal={Journal of AOAC International},
  year={2006},
  volume={89 4},
  pages={1116-9}
}
A reliable and sensitive method was developed for determination of nitroimidazoles in porcine urine. Sample preparation involves an extraction with ethyl acetate, followed by a solid-phase extraction cleanup step. The final extract is injected into the liquid chromatography/tandem mass spectrometry system in the positive-ion electrospray ionization mode. A C8 column with water and acetonitrile as the mobile phase is used for chromatographic separation under gradient conditions. Overall average… CONTINUE READING