Determination of nitrogen mustard hydrolysis products in rat urine samples using GC-MS.

@article{Kenar2011DeterminationON,
  title={Determination of nitrogen mustard hydrolysis products in rat urine samples using GC-MS.},
  author={Levent Kenar and Orkun Alp},
  journal={Journal of chromatographic science},
  year={2011},
  volume={49 5},
  pages={361-4}
}
A gas chromatographic-mass spectrometric method was developed, validated and demonstrated by measuring the levels of nitrogen mustard hydrolysis products in the urine collected from dosed rats. The recovery values for trimethylsilyl derivatives of EDEA and MDEA are between 82-95% and 88-112%, respectively. In vivo studies performed by using three different… CONTINUE READING