Determination of nimodipine in human plasma by a sensitive and selective liquid chromatography-tandem mass spectrometry method.

@article{Qiu2004DeterminationON,
  title={Determination of nimodipine in human plasma by a sensitive and selective liquid chromatography-tandem mass spectrometry method.},
  author={Feng Qiu and Xiaoyan Chen and Xiaoyan Li and Da-fang Zhong},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2004},
  volume={802 2},
  pages={291-7}
}
A sensitive and highly selective liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed to determine nimodipine in human plasma. The analyte and internal standard nitrendipine were extracted from plasma samples by n-hexane-dichloromethane-isopropanol (300:150:4, v/v/v), and chromatographed on a C(18) column. The mobile phase consisted of methanol-water-formic acid (80:20:1, v/v/v). Detection was performed on a triple quadrupole tandem mass spectrometer by selected… CONTINUE READING