Determination of nimetazepam and 7-aminonimetazepam in human urine by using liquid chromatography-tandem mass spectrometry.

@article{Wang2013DeterminationON,
  title={Determination of nimetazepam and 7-aminonimetazepam in human urine by using liquid chromatography-tandem mass spectrometry.},
  author={Kuang-Chuan Wang and Min-Chi Cheng and Chin-Lin Hsieh and Jung-Fa Hsu and Jen-Der Wu and C. Lee},
  journal={Forensic science international},
  year={2013},
  volume={224 1-3},
  pages={
          84-9
        }
}
We report determination of metabolites of popular drugs of abuse, including nimetazepam and nitrazepam, in urine by using liquid chromatography/mass spectrometry. Nimetazepam and its metabolites, 7-aminonimetazepam and nitrazepam, were extracted by solid-phase extraction using a DAU cartridge. An ammonium acetate buffer solution (pH 4) and a Luna polar-RP column were selected as the mobile and stationary phase, respectively, for liquid chromatography. Mass spectrometry was used for analysis and… Expand
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