Determination of methimazole in urine with the iodine-azide detection system following its separation by reversed-phase high-performance liquid chromatography.

@article{Zakrzewski2008DeterminationOM,
  title={Determination of methimazole in urine with the iodine-azide detection system following its separation by reversed-phase high-performance liquid chromatography.},
  author={Robert Zakrzewski},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2008},
  volume={869 1-2},
  pages={67-74}
}
The iodine-azide detection system to determine methimazole following its separation by RP-HPLC is described in this paper. The reaction between iodine and azide ions induced by methimazole was applied as a post-column reaction detection system. Neither extraction nor preconcentration of the sample was necessary. The methimazole standards added to normal urine show that the response of the detector, set at 350 nm (corresponding to unreacted iodine in the post-column iodine-azide reaction), was… CONTINUE READING
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