Determination of mangiferin in rat plasma by liquid-liquid extraction with UPLC-MS/MS.

  title={Determination of mangiferin in rat plasma by liquid-liquid extraction with UPLC-MS/MS.},
  author={Dandan Han and Chengjun Chen and Yu Zhang and Yanjiao Wang},
  journal={Journal of pharmaceutical and biomedical analysis},
  volume={51 1},
An ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method employing electrospray ionization (ESI) has been developed for the determination of mangiferin in rat plasma using diphenhydramine as the internal standard (IS). Liquid-liquid extraction (LLE) was used for sample preparation and the analysis was achieved with gradient elution on C(18) reversed phase column. The method was validated over the concentration range 0.02-5.0 microg/mL for oral administration and 0… CONTINUE READING
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