Determination of loxapine in human plasma and urine and identification of three urinary metabolites.

@article{Cooper1979DeterminationOL,
  title={Determination of loxapine in human plasma and urine and identification of three urinary metabolites.},
  author={Syretha F. Cooper and Robert Dugal and Michel J Bertrand},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1979},
  volume={9 7},
  pages={405-14}
}
1. A g.l.c. method for quantitative determination of loxapine (2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine), in human plasma and urine is described. 2. Preliminary pharmacokinetic data on plasma concn of loxapine over 12 h from five psychiatric patients who received a total average dose of 80 mg of loxapine succinate per day orally for twelve weeks are presented. 3. In addition to unchanged loxapine, three urinary metabolic products, namely aromatic ring-hydroxy loxapine… CONTINUE READING