Determination of low levels of amorphous content in inhalation grade lactose by moisture sorption isotherms.

  title={Determination of low levels of amorphous content in inhalation grade lactose by moisture sorption isotherms.},
  author={J. C. Vollenbroek and Gerald A Hebbink and Susanne Ziffels and Hartwig Steckel},
  journal={International journal of pharmaceutics},
  volume={395 1-2},
Alpha-lactose monohydrate is widely used as an excipient in dry powder inhalers, and plays a very important role in the efficiency of the drug delivery. Due to the processing, low levels of amorphous lactose could be present in the blends. Varying amounts could have a strong effect on the efficiency of drug delivery of the powder blends. Therefore, the accurate measurement of low levels of amorphous lactose content is very important. A new method was developed to measure the amorphous content… CONTINUE READING


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