Determination of lovastatin hydroxy acid in female B6C3F1 mouse serum.

@article{Lodge2008DeterminationOL,
  title={Determination of lovastatin hydroxy acid in female B6C3F1 mouse serum.},
  author={Jon W Lodge and Brenda L. Fletcher and Sherri S Brown and Angela J Parham and Reshan A. Fernando and Bradley J. Collins},
  journal={Journal of analytical toxicology},
  year={2008},
  volume={32 3},
  pages={248-52}
}
A liquid chromatographic-mass spectrometricmethod for the determination of lovastatin hydroxy acid in female B6C3F(1) mouse serum was developed for use in supporting toxicokinetic studies of animals dosed with the cholesterol lowering agent lovastatin. The method does not require an extensive sample cleanup and shows good correlation between serum matrix standards and solvent standards. The method was validated and used to analyze serum samples from a preliminary dose level range-finding study… CONTINUE READING