• DOI:10.1016/j.tiv.2014.05.009
Corpus ID: 10162839

Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment.

@article{Germano2015DeterminationOL,
  title={Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment.},
  author={D. Germano and M. Uteng and F. Pognan and S. Chibout and A. Wolf},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2015},
  volume={30 1 Pt A},
  pages={
          79-94
        }
}

D. Germano, M. Uteng, +2 authors A. Wolf

Published 2015

Medicine

Toxicology in vitro : an international journal published in association with BIBRA

DILI is a major safety issue during drug development and one of the leading causes for market withdrawal. Despite many efforts made in the past, the prediction of DILI using in vitro models remains very unreliable. In the present study, the well-established hepatocyte Collagen I-Matrigel™ sandwich culture was used, mimicking chronic drug treatment after multiple incubations for 14 days. Ten drugs associated with different types of specific preclinical and clinical liver injury were evaluated at… CONTINUE READING

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