Determination of liver intracellular pH in vivo and its homeostasis in acute acidosis and alkalosis.

@article{Park1979DeterminationOL,
  title={Determination of liver intracellular pH in vivo and its homeostasis in acute acidosis and alkalosis.},
  author={Richard Park and William Joseph Leach and Allen Israel Arieff},
  journal={The American journal of physiology},
  year={1979},
  volume={236 3},
  pages={F240-5}
}
An in vivo method is presented for the determination of liver intracellular pH (pHi) using [14C]dimethadione (DMO) in dogs. This method differs from those previously published in that hepatic venous and portal venous blood pH were selected as the extracellular reference pH, and liver blood space corrections are applied to whole liver tissue [14C]DMO activity. Using these corrections, a normal liver pHi of 6.99 +/- 0.03 (SE) was obtained. During acute metabolic acidosis and alkalosis, as well as… CONTINUE READING
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