Determination of limonin in rat plasma by liquid chromatography-electrospray mass spectrometry.

@article{Liang2005DeterminationOL,
  title={Determination of limonin in rat plasma by liquid chromatography-electrospray mass spectrometry.},
  author={Yan Liang and Lin Xie and Xiao-Dong Liu and Tong Lu and Guang-ji Wang and Yu-zhu Hu},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2005},
  volume={39 5},
  pages={
          1031-5
        }
}
A simple, sensitive and selective liquid chromatography coupled with electrospray ionization mass spectrometry (LC/ESI/MS) method for determination of limonin (LM) in rat plasma has been developed and validated. The method had advantages of a single liquid-liquid extraction with ether and high sensitivity. Analyses were conducted at a flow rate of 0.2 ml/min by a gradient elution. The detection utilized selected ion monitoring in the negative ion mode at m/z 460.00 and 423.15 for the… CONTINUE READING