Determination of lidocaine and its two N-desethylated metabolites in dog and horse plasma by high-performance liquid chromatography combined with electrospray ionization tandem mass spectrometry.

@article{Maes2007DeterminationOL,
  title={Determination of lidocaine and its two N-desethylated metabolites in dog and horse plasma by high-performance liquid chromatography combined with electrospray ionization tandem mass spectrometry.},
  author={An A Maes and Linda Weiland and Charlotte Sandersen and Frank M R Gasthuys and Patrick de Backer and Siska Croubels},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2007},
  volume={852 1-2},
  pages={180-7}
}
A sensitive method for the quantification of lidocaine and its metabolites, monoethylglycinexylidide (MEGX) and glycinexylidide (GX), in animal plasma using high-performance liquid chromatography combined with electrospray ionization mass spectrometry is described. The sample preparation includes a liquid-liquid extraction with methyl tert-butylmethyl ether after addition of 2M sodium hydroxide. Ethylmethylglycinexylidide (EMGX) is used as an internal standard. For chromatographic separation… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-7 of 7 references

Reg

  • T. Fukuda, Y. Kakiuchi, +4 authors H. Toyooka
  • Anesth. Pain. Med. 25
  • 2000
Highly Influential
4 Excerpts

Med

  • L. Weiland, S. Croubels, +4 authors J. Vet
  • A 53
  • 2006

Vet

  • A. Valverde, T. J. Doherty, J. Hernandez, W. Davies
  • Anaesth. Analg. 31
  • 2004
2 Excerpts

Br

  • R. Orlando, P. Piccoli, S. De Martin, R. Padrini, P. Palatini
  • J. Clin. Pharmacol. 55
  • 2003
1 Excerpt

Pharmacol

  • J. R. Wilcke, L. E. Davis, C. A. Neff-Davis, J. Vet
  • Ther. 6
  • 1983
2 Excerpts

Clin

  • P. K. Narang, W. G. Crouthamel, N. H. Carliner, M. L. Fisher
  • Pharmacol. Ther. 24
  • 1978
2 Excerpts

/ 657 / EC ) of 17 august 2002 implementing Council Directive 96 / 23 / EC concerning the performance of analytical methods and the interpretation of results , Off

  • M. Bielenstein Abdel-Rehim, Y. Askemark, N. Tyrefors, T. Arvidsson, J. Chromatogr
  • J . Eur . Commun . No . L

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