Determination of levocetirizine in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study.

@article{Morita2008DeterminationOL,
  title={Determination of levocetirizine in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study.},
  author={Michio Morita and Danilo Cortozi Berton and Robert J. Boldin and F{\'a}bio Alessandro Proença Barros and E C Meurer and Ant{\^o}nio Ricardo Amarante and David R Campos and Silvana Aparecida Calafatti and Renata Virginia Ferreira Pereira and Eduardo Cintra Abib and J Pedrazolli},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2008},
  volume={862 1-2},
  pages={
          132-9
        }
}
We describe a liquid chromatography-tandem mass spectrometric method (LC-MS/MS) for levocetirizine quantification (I) in human plasma. Sample preparation was made using a fexofenadine (II) addition as internal standard (IS), liquid-liquid extraction using cold dichloromethane, and dissolving the final extract in acetonitrile. I and II (IS) were injected in a C18 column and the mobile phase composed of acetonitrile:water:formic acid (80.00:19.90:0.10, v/v/v) and monitored using positive… CONTINUE READING
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