Determination of leukotriene A4 stabilization by S100A8/A9 proteins using mass spectrometry

@article{Rector2009DeterminationOL,
  title={Determination of leukotriene A4 stabilization by S100A8/A9 proteins using mass spectrometry},
  author={Christopher L. Rector and Robert C. Murphy},
  journal={Journal of Lipid Research},
  year={2009},
  volume={50},
  pages={2064 - 2071}
}
Leukotriene A4 (LTA4) is the precursor for the formation of bioactive leukotrienes, but is highly susceptible to nonenzymatic hydrolysis. Although it is chemically reactive, LTA4 participates in the process of transcellular metabolism, which requires the transfer of LTA4 from one cell to another for the production of additional leukotrienes. Due to the susceptibility of LTA4 to hydrolysis, various methods have been used to measure the half-life of LTA4 in the presence of different proteins in… Expand
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