Determination of left–right patterning of the mouse embryo by artificial nodal flow

@article{Nonaka2002DeterminationOL,
  title={Determination of left–right patterning of the mouse embryo by artificial nodal flow},
  author={Shigenori Nonaka and Hidetaka Shiratori and Yukio Saijoh and Hiroshi Hamada},
  journal={Nature},
  year={2002},
  volume={418},
  pages={96-99}
}
Substantial insight has recently been achieved into the mechanisms responsible for the generation of left–right (L–R) asymmetry in the vertebrate body plan. However, the mechanism that underlies the initial breaking of symmetry has remained unclear. In the mouse, a leftward fluid flow on the ventral side of the node caused by the vortical motion of cilia (referred to as nodal flow) is implicated in symmetry breaking, but direct evidence for the role of this flow has been lacking. Here we… Expand
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