Determination of lamotrigine in whole blood with on line solid phase extraction.

@article{Bompadre2008DeterminationOL,
  title={Determination of lamotrigine in whole blood with on line solid phase extraction.},
  author={Stefano Bompadre and Adriano Tagliabracci and Maurizio Battino and Raffaele Giorgetti},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2008},
  volume={863 1},
  pages={177-80}
}
A simple, sensitive and reproducible method was developed for the determination of lamotrigine in whole blood with on-line solid phase extraction followed by HPLC separation with UV detection. Whole blood samples were diluted 1:1 with water and then injected directly on a clean-up column dry-packed with 40microm C8 silica and separated on a C18 reversed-phase column (150x4.6mm) at room temperature. The extraction column was activated with methanol and conditioned with phosphate buffer of pH 4.5… CONTINUE READING