Determination of ivermectin in human plasma by high-performance liquid chromatography.

@article{Krishna1993DeterminationOI,
  title={Determination of ivermectin in human plasma by high-performance liquid chromatography.},
  author={Devarakonda R. Krishna and Ulrich Klotz},
  journal={Arzneimittel-Forschung},
  year={1993},
  volume={43 5},
  pages={609-11}
}
A specific reversed-phase HPLC-assay with sensitive fluorometric detection has been developed to measure the potent new antiparasitic agent ivermectin (CAS 70288-86-7) in human plasma (and urine). The lower limit of the method was 1 ng/ml and the intra-/interassay variability averaged 4.5/6.9%, respectively. The assay was applied for measuring plasma (urine… CONTINUE READING