Determination of itraconazole in human plasma by high-performance liquid chromatography with solid-phase extraction.

@article{Ohkubo2005DeterminationOI,
  title={Determination of itraconazole in human plasma by high-performance liquid chromatography with solid-phase extraction.},
  author={Tadashi Ohkubo and Takako Osanai},
  journal={Annals of clinical biochemistry},
  year={2005},
  volume={42 Pt 2},
  pages={94-8}
}
BACKGROUND A practical, simple, high-performance liquid chromatographic (HPLC) method is needed for the determination of itraconazole in clinical plasma samples. METHODS Itraconazole and bifonazole (internal standard) were extracted from plasma using a C8-bonded solid-phase cartridge, separated by C8 reversed-phase HPLC, and quantified by ultraviolet… CONTINUE READING