Determination of isopropylthioxanthone (ITX) in milk, yoghurt and fat by HPTLC-FLD, HPTLC-ESI/MS and HPTLC-DART/MS

  title={Determination of isopropylthioxanthone (ITX) in milk, yoghurt and fat by HPTLC-FLD, HPTLC-ESI/MS and HPTLC-DART/MS},
  author={G. Morlock and W. Schwack},
  journal={Analytical and Bioanalytical Chemistry},
AbstractTwo new HPTLC methods for quantification of isopropyl-9H-thioxanthen-9-one (ITX) in milk, yoghurt and fat samples have been developed. Extraction of ITX from milk and yoghurt was performed with a mixture of cyclohexane and ethyl acetate by employment of accelerated solvent extraction (ASE). For soy bean oil and margarine, a simple partitioning of ITX into acetonitrile was used. ITX and 2,4-diethyl-9H-thioxanthen-9-one (DTX) used as internal standard have been separated on silica gel 60… Expand
Determination of 2-isopropyl thioxanthone and 2-ethylhexyl-4-dimethylaminobenzoate in milk: comparison of gas and liquid chromatography with mass spectrometry
Both GC-MS and LC-MS/MS were suitable to determine these photoinitiators in the PLE extracts, providing appropriate identification and quantification and pointed out that both techniques are appropriate to determineThese compounds in food samples. Expand
Determination of isopropyl-9H-thioxanthen-9-one in packaged beverages by solid-phase extraction clean-up and liquid chromatography with tandem mass spectrometry detection.
Excellent validation data suggest the exciting possibility of using this method for the determination of low levels of ITX migrating from printed food packaging materials into beverages with a method quantitation limit of 0.50 microg/kg. Expand
2-Isopropylthioxanthone (2-ITX) in food and food packaging materials on the German market
To elucidate the occurrence of the photo-initiator, 2-isopropylthioxanthone (2-ITX), more than 100 food products on the German market, packed in cartons, plastic cups and foils, were investigated.Expand
Direct analysis of isopropylthioxanthone (ITX) in milk by high-performance liquid chromatography/tandem mass spectrometry.
A fast screening method is presented for detecting isopropylthioxanthone (ITX) contamination in milk using direct high-performance liquid chromatography/tandem mass spectrometry analysis of milk samples, which is highly accurate and sensitive. Expand
A packaging contaminant: isopropylthioxanthone (ITX) in dairy products.
A fast, simple and very selective liquid chromatography-mass spectrometry (LC-MS) method for the detection of isopropylthioxanthone (ITX) in dairy products has been developed and validated. AfterExpand
Analysis of benzophenone and 4-methylbenzophenone in breakfast cereals using ultrasonic extraction in combination with gas chromatography-tandem mass spectrometry (GC-MS(n)).
A fast and reliable method is described that is able to detect both BP and 4MBP at very low concentrations (LOD=2microg kg(-1)) in breakfast cereals. Expand
Simultaneous determination of caffeine, ergotamine, and metamizol in solid pharmaceutical formulation by HPTLC-UV-FLD with mass confirmation by online HPTLC-ESI-MS.
The results proved that this high-throughput method to quantify caffeine, ergotamine, and metamizol in a solid pharmaceutical formulation is a simple and reliable alternative for routine analysis. Expand
Liquid chromatography/tandem mass spectrometry (highly selective selected reaction monitoring) for the analysis of isopropylthioxanthone in packaged food.
The use of highly selective selected reaction monitoring (H-SRM on Q1) resulted in improved selectivity without sensitivity loss and good run-to-run precision and limits of detection down to 0.8pg injected in the LC-MS/MS system were obtained. Expand
A Comparison of Soxhlet Extraction and Ultrasonic-Assisted Extraction for Analysis of Photoinitiators in Printed Cartonboard Food-Packaging Materials
A new method was established for detecting a series of photoinitiators (PIs) in printed cartonboard food-packaging materials, which were benzophenone (BP), 4-methylbenzophenone (MBP),Expand
Quantitation and human monocyte cytotoxicity of the polymerization agent 1-hydroxycyclohexyl phenyl ketone (Irgacure 184) from three brands of aqueous injection solution.
The findings suggest that 1-HCHPK could promote adverse events in patients and the amount of contaminants from plastic containers such as those used for peripheral parenteral nutrition and to determine the cytotoxicity of such extracts on human monocytes. Expand


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