Determination of intrinsic transcription termination efficiency by RNA polymerase elongation rate.

@article{McDowell1994DeterminationOI,
  title={Determination of intrinsic transcription termination efficiency by RNA polymerase elongation rate.},
  author={Jennifer C. McDowell and Jeffrey W. Roberts and Ding Jun Jin and Carol Gross},
  journal={Science},
  year={1994},
  volume={266 5186},
  pages={822-5}
}
Transcription terminators recognized by several RNA polymerases include a DNA segment encoding uridine-rich RNA and, for bacterial RNA polymerase, a hairpin loop located immediately upstream. Here, mutationally altered Escherichia coli RNA polymerase enzymes that have different termination efficiencies were used to show that the extent of transcription through the uridine-rich encoding segment is controlled by the substrate concentration of nucleoside triphosphate. This result implies that the… CONTINUE READING

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