Determination of interleukin-5 secretion from drug-specific activated ex vivo peripheral blood mononuclear cells as a test system for the in vitro detection of drug sensitization.

Abstract

BACKGROUND In vitro detection of drug sensitization is still limited. The lymphocyte transformation test, which determines drug-specific proliferation, is the only in vitro test for detecting drug sensitization at the cellular level irrespective of the reaction's clinical phenotype. Accumulation of eosinophils following IL-5 secretion from drug-specific… (More)

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@article{Sachs2002DeterminationOI, title={Determination of interleukin-5 secretion from drug-specific activated ex vivo peripheral blood mononuclear cells as a test system for the in vitro detection of drug sensitization.}, author={Bernd Sachs and Stephan Michael Erdmann and J Malte Baron and Mark M Neis and Tames Al Masaoudi and Herbert Merk}, journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology}, year={2002}, volume={32 5}, pages={736-44} }