Determination of individual homologues and total content of benzalkonium chloride by reversed-phase high-performance liquid chromatography using a short butyl column.

@article{Liu2009DeterminationOI,
  title={Determination of individual homologues and total content of benzalkonium chloride by reversed-phase high-performance liquid chromatography using a short butyl column.},
  author={Fangzhu Liu and Kang Ping Xiao and Abu Mohammad Rustum},
  journal={Journal of AOAC International},
  year={2009},
  volume={92 6},
  pages={
          1644-51
        }
}
Benzalkonium chloride (a mixture of alkylbenzyldimethylammonium chlorides that usually contains C-10, C-12, C-14, and C-16 homologues), commonly known as BKC, is used as a bacteriostatic agent in many household, food, and drug products. In this paper, we report a simple, rapid, robust, and stability-indicating reversed-phase HPLC method using a short butyl (C4) column for the simultaneous determination of each individual homologue content, as well as the total concentration of individual… CONTINUE READING