Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique.

@article{Richter2001DeterminationOI,
  title={Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique.},
  author={Oliver von Richter and Barbara Greiner and Martin F. Fromm and Robert Fraser and Taher Al Omari and Murray Lindsay Barclay and John Dent and Andrew Alexander Somogyi and Michel F Eichelbaum},
  journal={Clinical pharmacology and therapeutics},
  year={2001},
  volume={70 3},
  pages={217-27}
}
BACKGROUND AND AIMS The contribution of the gastrointestinal tract in comparison with the liver for the low and variable bioavailability of orally administered drugs is still poorly understood. Here we report on a new intestinal perfusion technique for the direct assessment of absorption, metabolism, and transport of drugs by the intestinal wall. METHODS In 6 healthy volunteers a multilumen perfusion catheter was used to generate a 20-cm isolated jejunal segment that was perfused with 80 mg… CONTINUE READING