Determination of immunoglobulin A against Gardnerella vaginalis hemolysin, sialidase, and prolidase activities in vaginal fluid: implications for adverse pregnancy outcomes.

@article{Cauci2003DeterminationOI,
  title={Determination of immunoglobulin A against Gardnerella vaginalis hemolysin, sialidase, and prolidase activities in vaginal fluid: implications for adverse pregnancy outcomes.},
  author={Sabina Cauci and Poul Thorsen and Diana Elizabeth Schendel and Annie Bremmelgaard and Franco Quadrifoglio and Secondo Guaschino},
  journal={Journal of clinical microbiology},
  year={2003},
  volume={41 1},
  pages={435-8}
}
A nested case-control study of low birth weight and preterm delivery was performed with singleton women. Immunoglobulin A (IgA) against the Gardnerella vaginalis hemolysin (anti-Gvh IgA) and sialidase and prolidase activities were determined in vaginal fluid at 17 weeks of gestation. Sialidase positivity and bacterial vaginosis with high prolidase activity were associated with 2- and 11-fold increased risks for low birth weight, respectively. No woman with bacterial vaginosis plus a strong anti… CONTINUE READING

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