Determination of homozygosity or heterozygosity for the G2m(n) allotype by a monoclonal, precipitating antibody.

@article{Rautonen1989DeterminationOH,
  title={Determination of homozygosity or heterozygosity for the G2m(n) allotype by a monoclonal, precipitating antibody.},
  author={Nina E Rautonen and Ilkka Sepp{\"a}l{\"a} and Tomas Hallberg and Rune Grubb and Olli T M{\"a}kel{\"a}},
  journal={Experimental and clinical immunogenetics},
  year={1989},
  volume={6 1},
  pages={31-8}
}
Monoclonal antibody SH 21 was found to be a good anti-IgG2m(n) reagent both for the conventional typing (HA inhibition) and for precipitation in polyethylene glycol containing gel. Antibody SH 21, together with monoclonal antibody HP 6014 (anti-IgG2), was used for the discrimination between G2m(+n) homozygotes and heterozygotes in a double diffusion assay, where the two antibodies and a serum sample were placed in corners of a triangle. In the case of a homozygote SH 21 was able to stop the… CONTINUE READING

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