Determination of hepatotoxic pyrrolizidine alkaloids by on-line high performance liquid chromatography mass spectrometry with an electrospray interface.

@article{Lin1998DeterminationOH,
  title={Determination of hepatotoxic pyrrolizidine alkaloids by on-line high performance liquid chromatography mass spectrometry with an electrospray interface.},
  author={Ge Lin and Kai Ya Zhou and Xin Zhao and Zheng Tao Wang and Paul Pui-Hay But},
  journal={Rapid communications in mass spectrometry : RCM},
  year={1998},
  volume={12 20},
  pages={1445-56}
}
The present study describes the determination of two different types of hepatotoxic pyrrolizidine alkaloids (PAs) and also distinguishing the hepatotoxic PAs from non-toxic ones by both in-source collision-induced dissociation high performance liquid chromatography mass spectrometry (CID-HPLC/MS) and HPLC/MS/MS (CID in the collision cell), using electrospray ionization. The mass spectra provided molecular ions and characteristic fragment ions, which could be used readily for a rapid… CONTINUE READING