Determination of guanfacine in biological fluids by electron-capture GLC.

@article{Guerret1979DeterminationOG,
  title={Determination of guanfacine in biological fluids by electron-capture GLC.},
  author={Madeleine Guerret and Daniele Lavene and J E Longchampt and J L Kiger},
  journal={Journal of pharmaceutical sciences},
  year={1979},
  volume={68 2},
  pages={219-21}
}
A quantitative electron-capture GLC method with good sensitivity is described for the determination of guanfacine in human plasma and urine. By condensing its amidino group with hexafluoroacetylacetone, guanfacine is converted to a pyrimidino derivative with better GLC properties than the parent drug. This method allows the determination of guanfacine in plasma and urine at concentrations as low as 0.5 ng/ml and was applied successfully to measurement of plasma levels in humans after… CONTINUE READING