Determination of glutathionyl hemoglobin in hemodialysis patients using electrospray ionization liquid chromatography-mass spectrometry.

@article{Naito1999DeterminationOG,
  title={Determination of glutathionyl hemoglobin in hemodialysis patients using electrospray ionization liquid chromatography-mass spectrometry.},
  author={Chitose Naito and Mitsuharu Kajita and Toshimitsu Niwa},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  year={1999},
  volume={731 1},
  pages={121-4}
}
We first detected glutathionyl hemoglobin (Hb) beta-chain in hemodialysis patients and healthy subjects using electrospray ionization liquid chromatography-mass spectrometry. The ratio of glutathionyl Hb beta-chain to total beta-chain was markedly increased in the hemodialysis patients as compared with healthy subjects. Glutathionyl Hb will be used as a new clinical marker of oxidative stress.